Mechanism of action of tidulutide Gattex (teduglutide)

Teduglutide is a natural human analogue of glucagon-like peptide-2 (GLP-2), a peptide secreted by L cells in the distal gut. GLP-2 is known to improve intestinal and portal blood flow and inhibit gastric acid secretion. For degrees of lu peptide and peptide receptor 2 glucagon samples, insulin-like growth factor in intestinal endocrine cells, epithelial cells of muscle fiber, submucosa and myenteric stands between intestinal neurons. The activation of these receptors causes the local release of a variety of media, including insulin-like growth factor (IGF) 1, cell growth factor formation nitrogen oxide and cutin cell growth factor (KGF).

Tidulutide, a glucagon-like peptide 2 (GLP-2) analogue, reduces gastric emptying and metabolism and regulates the growth, reproduction and recovery of intestinal lining cells. Peptide increased the total number of these cells, can increase the absorption of small intestine, reduce diarrhea. Short bowel syndrome in adults can be treated clinically. The drug has become the first recommended drugs to a rare but extremely weak.

A brief introduction to tidulutide

Chemical molecular formula of tidulutide

Basic parameters

Name: for c peptide (Teduglutide)

Number: GT – F027

CAS number: 197922-42-2

Sequence: His-Gly-Asp-Gly-Ser-Phe-Ser-Asp-Glu-Met-Asn-Thr-Ile-Leu-Asp-Asn-Leu-Ala-Ala-Arg-Asp-Phe-Ile-Asn-Trp-Leu-Ile-Gln-Thr-Lys- Ile-Thr-Asp

Molecular formula: C164H252N44O55S

Molecular weight: 3752.08248